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教师内容页
张磊  
研究领域(方向)
蛋白质结构与功能
个人及工作简历

教育经历

2003.7 乐动体育平台官网    理学学士       应用物理学

2006.5 乐动体育平台官网   理学硕士       理论物理(斑图动力学)

2010.6 乐动体育平台官网    理学博士        凝聚态物理(电子显微镜学)

2008-2010   美国加州大学旧金山分校    联合培养博士      蛋白结构与功能(电子显微镜)

2011-2014    美国劳伦斯伯克利国家实验室     博士后        蛋白结构与功能(电子显微镜)

工作经历

2011.1–2014.1  博士后研究员  美国劳伦斯伯克利国家实验室材料科学部,纳米中心

2014.2–2015.9  项目科学家    美国劳伦斯伯克利国家实验室材料科学部,纳米中心

2015.9–   今   物理学教授    乐动体育平台官网理学院应用物理系

人才称号:

2015  入选乐动体育平台官网“青年拔尖人才A类计划”

2019    获得国家自然科学基金委“优秀青年科学基金项目”支持

科研项目

1. 国家自然科学基金重点项目,11834018,DNA损伤修复中的若干关键物理问题及单

分子解决方案,2019/1-2023/12,310万元,在研,参加

2. 国家自然科学基金面上项目,11774279,初生态盘状高密度脂蛋白结构与功能关

系的微观物理机理研究,2018/1-2021/12,70万元,在研,主持

3. 国家自然科学基金应急管理项目,11747603,“第十四期理论物理专题讲学”活

动,2018/1-2018/12,35万元,已结题,主持

4. 国家自然科学基金青年科学基金项目,11504287,9.6nm高密度脂蛋白结构与功能的透射电子显微镜与分子动力学模拟研究,2016/1-2018/12,24万元,已结题,主持

学术及科研成果、专利、论文

代表性论文:

1.   Minggang Xia, Shengli Zhang, Xianjun Zuo, Erhu Zhang, Shumin Zhao, Jian Li, Lei Zhang, Yachao Liu, and Run Liang, Assignment of the chiralities of double-walled carbon nanotubes using two radial breathing modes, Phys. Rev. B 70(20), 205428 (2004). (IF: 3.836; Cited: 11)

2.   Shengli Zhang, Lei Zhang, Run Liang, Erhu Zhang, Yachao Liu, and Shumin Zhao, Lubricating bacteria model for the growth of bacterial colonies exposed to ultraviolet radiation, Phys. Rev. E 72(5), 051913 (2005). (IF: 2.366; Cited: 2)

3.   Shengli Zhang, Run Liang, Erhu Zhang, Lei Zhang, and Yachao Liu, Magnetosubbands of semiconductor quantum wires with Rashba and Dresselhaus spin-orbit coupling, Phys. Rev. B 73(15), 155316 (2006). (IF: 3.836; Cited: 35)

4.  Shumin Zhao, Shengli Zhang, Zhenwei Yao, and Lei Zhang, Equilibrium conformation of polymer chains with noncircular cross section, Phys. Rev. E 74(3), 032801 (2006). (IF: 2.366; Cited: 16)

5.   Youli Yu, Lei Zhang, and Zhenxi Zhang, Computation for Optical Trap Stiffness Versus Refractive Index of Biological Cell, Acta. Optica. Sinica. 27(6), 1076 (2007). ( Cited: 4)

6.   Shengli Zhang, Yachao Liu, Minggang Xia, Lei Zhang, Erhu Zhang, Run Liang, and Shumin Zhao, Long-wavelength optical phonons in single-walled boron nitride nanotubes, Physica B 403(23-24), 4196-4201 (2008). (IF: 1.386; Cited: 2)

7.   Minggang Xia, Lei Zhang, and Shengli Zhang, Effect of optical phonons scattering on electronic current in metallic carbon nanotubes, Physics Lett. A 373(3), 385-390 (2009). (IF: 1.772; Cited: 4)

8.    Lei Zhang, Shengli Zhang, Huimin Tong, Dongsheng Lei, and Bambi Hu, Spontaneously periodic wave generation in coupled excitable media, Phys. Rev. E 79(5), 056213 (2009). (IF: 2.366; Cited: 2)

9.  Lei Zhang, James Song, Yvonne Newhouse, Shengli Zhang, Karl H. Weisgraber, and Gang Ren, An optimized negative-staining protocol of electron microscopy for apoE4•POPC lipoprotein, Journal. Lipid Research 51(5), 1228-1236 (2010). (IF: 4.81; Cited: 31)

10.  Martin K. Jones, Lei Zhang, Andrea Catte, Ling Li, Michael N .Oda, Gang Ren, and Jere P. Segrest, Assessment of the Validity of the Double Superhelix Model for Reconstituted High Density Lipoproteins: A COMBINED COMPUTATIONAL-EXPERIMENTAL APPROACH, Journal. Biological Chemistry 285(52), 41161-41171 (2010). (IF: 4.125; Cited: 33)

11.  Won Jin Cho, Jin-Sook Lee, Lei Zhang, Gang Ren, Leah Shin, Charles W. Manke, Jeffrey Potoff, Nato Kotaria, Mzia G. Zhvania, Bhanu P. Jena, Membrane-directed molecular assembly of the neuronal SNARE complex, Journal. Cellular and Molecular Medicine, 15(1), 31-37 (2011). (IF: 4.499; Cited: 18)

12.  Lei Zhang, James Song, Giorgio Cavigiolio, Brian Y.Ishida, Shengli Zhang, John P. Kane, Karl H. Weisgraber, Henry J. Pownall, Kerry-Anne Rye, Michael N.Oda, and Gang Ren, Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy, Journal. Lipid Research 52(1), 175-184 (2011). (IF: 4.81; Cited:49)

13. Xiaobo Zhai, Shengli Zhang, Lei Zhang, and Shumin Zhao, The optimal configuration of gel sheet governed by its concentration, Int. J. Mod. Phys. B 26(14): 1250084 (2012). (IF: 0.736; Cited: 1)    

14.  Lei Zhang and Gang Ren, IPET and FETR: Experimental Approach for Studying Molecular Structure Dynamics by Cryo-Electron Tomography of a Single-Molecule Structure, PLOS ONE, 7(1): e30249 (2012). (IF: 2.806; Cited: 52)

15.  Lei Zhang, Feng Yan, Shengli Zhang, Dongsheng Lei, M. Arthur Charles, Giorgio Cavigiolio, Michael Oda, Ronald M. Krauss, Karl H. Weisgraber, Kerry-Anne Rye, Henry J. Pownall, Xiayang Qiu, and Gang Ren. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein, Nature Chemical Biology, 8(4): 342-349 (2012). (IF:15.066; Cited: 65)

16. Lei Zhang and Gang Ren, High-resolution single-molecule structure revealed by electron microscopy and individual-particle electron tomography, J. Phys. Chem. Biophys, 2(2): DOI: 10.4172/2161-0398.2000e103 1000e103 (2012).

17. Huimin Tong, Lei Zhang, Liqing Huang, and Gang Ren, Optimized Negative-staining Protocol for Electron Microscopy Study of Lipoprotein Structure, Progress in Biochemistry and Biophysics, 39(10): 972-978 (2012). (IF:0.341; Cited: 1)

18. Lei Zhang, Huimin Tong, Mark Garewal, and Gang Ren, Optimized Negative-Staining Electron Microscopy for Lipoprotein studies, BBA-General Subjects 1830(1): 2150-2159 (2013). (IF:4.702; Cited: 17)

19. Dongsheng Lei, Xing Zhang, Shengbo Jiang, Zhaodi Cai, Matthew J. Rames, Lei Zhang, Gang Ren, and Shengli Zhang, Structural features of cholesteryl ester transfer protein: A molecular dynamics simulation study, Proteins: Structure, Function, and Bioinformatics 81(3): 415-425 (2013). (IF:2.289; Cited: 9)

20. Huimin Tong, Lei Zhang, Allan Kaspar, Matthew J. Rames, Liqing Huang, Gary Woodnutt, and Gang Ren, Peptide-Conjugation Induced Conformational Changes in Human IgG1 Observed by Optimized Negative-Staining and Individual-Particle Electron Tomography, Scientific Reports, 3: 1089 (2013). (IF:4.259; Cited:14)

21. Teng Zhang, Yunhui Peng, Huimin Tong, Matthew J. Rames, Lei Zhang, Gang Ren, IPET: an Experimental Method to Determine the 3-Dimensional Structure of an Individual Macromolecule, Progress in Chemistry, 25(05): 669-676 (2013). (IF:0.953; Cited:0)

22. Kang-Da Zhang, Jia Tian, David Hanifi, Yuebiao Zhang, Andrew Chi-Hau Sue, Tian-You Zhou, Lei Zhang, Xin Zhao, Yi Liu, and Zhan-Ting Li. Toward a Single-Layer Two-Dimensional Honeycomb Supramolecular Organic Framework in Water, Journal of The American Chemical Society,135(47): 17913-17918 (2013). (IF:13.858; Cited:121)

23. Dongsheng Lei, Huimin Tong, Lei Zhang, Xing Zhang, Shengli Zhang, and Gang Ren, Structure and Function of Cholesteryl Ester Transfer Protein in Transferring Cholesteryl Ester, Progress in Chemistry, 26(5):879-888 (2014). (IF:0.953; Cited:0)

24.  Debin Wang, Stacy L. Capehart, Suchetan Pal, Minghui Liu, Lei Zhang, P. James Schuck, Yan Liu, Hao Yan, Matthew B. Francis, and James J. De Yoreo, Hierarchical Assembly of Plasmonic Nanostructures Using Virus Capsid Scaffolds on DNA Origami Templates, ACS Nano, 8(8):7896-7904 (2014). (IF:13.942; Cited:15)

25. Zhuoyang Lu, Yun Wang, Fang Chen, Huimin Tong, M.V.V.V. Sekhar Reddy, Lin Luo, Suchithra Seshadrinathan, Lei Zhang, Luis Marcelo F. Holthauzen, Ann Marie Craig, Gang Ren.  and Gabby Rudenko, Calsyntenin3: Molecular Architecture and Interaction with Neurexin 1alpha, J. Biological Chemistry: 289(50):34530-34542 (2014). (IF:4.125; Cited:17)

26.Meng Zhang, River Charles, Huimin Tong, Lei Zhang, Mili Patel, Francis Wang, Matthew J. Rames, Amy Ren, Kerry-Anne Rye, Xiayang Qiu, DouglasG. Johns, M.Arthur Charles, and Gang Ren. HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation. Scientific Reports, 5:8741 (2015). (IF:4.259; Cited:15)

27. Xing Zhang#, Lei Zhang#, Huimin Tong, Bo Peng, Matthew J. Rames, Shengli Zhang, and Gang Ren. 3D structural fluctuation of IgG1 antibody revealed by individual particle electron tomography. Scientific Reports, 5: 9803 (2015). (IF:4.259; Cited:57)

28. Xing Zhang, Donsheng  Lei, Lei Zhang, Matthew Rames, and Shengli Zhang. A Model of Lipid-Free Apolipoprotein A-I Revealed by Iterative Molecular Dynamics Simulation. PLOS ONE, 10(3): e0120233 (2015). (IF:2.806; Cited:2)

29. Jere P. Segrest, Martin K. Jones, Andrea Catte, Medha Manchekar, Geeta Datta, Robin Zhang, Lei Zhang, Ling Li, James C. Patterson, Mayakonda N. Palgunachari, Jack F. Oram, and Gang Ren, Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly. Structure, 23(7): 1214-1226 (2015). (IF:4.945; Cited:11)

30.Lei  Zhang, Dongsheng  Lei,  Jessica M. Smith,  Meng  Zhang, Huimin  Tong,  Xing  Zhang,  Zhuoyang Lu, Jiankang Liu, Paul A. Alivisatos, and Gang Ren, Three-dimensional structural dynamics and fluctuations of DNA-nanogold conjugates by individual-particle electron tomography. Nature Communications, 7:11083 (2016). (IF:12.124; Cited:6)

31. Zhiwei Yang, Fei Wu, Xiaohui Yuan, Lei Zhang, and Shengli Zhang, Novel binding patterns between ganoderic acids and neuraminidase: Insights from docking, molecular dynamics and MM/PBSA studies. Journal of Molecular Graphics & Modelling, 65: 27-34 (2016).(IF:1.754;Cited:5)

32. Dongsheng  Lei, Mattehw  Rames, Xing  Zhang, Lei Zhang, Shengli  Zhang, and Gang  Ren, Insights into the tunnel mechanism of cholesteryl ester transfer protein through all-atom molecular dynamics simulations. J. Biological Chemistry, 291(27):14034-14044 (2016). (IF:4.125; Cited:4)

33. Xing Zhang, Yuheng Liao, Huimin Tong, Lei Zhang, Shengli Zhang, and Gang Ren, 3D Reconstruction and Structural Study of IgG1 Antibody by Individual-particle Electron Tomography. Progress in Biochemistry and Biophysics, 43(9): 839-849 (2016).(IF:0.341; Cited:0)

34. Zhuoyang Lu, M. V. V. V. Sekhar Reddy, Jianfang Liu, Ana Kalichava, Jiankang Liu, Lei Zhang, Fang Chen, Yun Wang, Luis Marcelo F. Holthauzen, Mark A. White, Suchithra Seshadrinathan, Xiaoying Zhong, Gang Ren, and Gabby Rudenko, Molecular architecture of contactin-associated protein-like 2 (cntnap2) and its interaction with contactin 2 (cntn2). J. Biological Chemistry, 291(46): 24133-24147 (2016).(IF:4.125; Cited:7)

35. Mingxing Wang#, Guoyin Li#, Zhiwei Yang, # Lei Wang, Lei Zhang, Ting Wang, Yimeng Zhang, Shengli Zhang, Yong Han*, and Lintao Jia*, Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer. Oncotarget, 8(5):8083-8094, 2017.

36. Zhiwei Yang, Lu Gou, Shuyu Chen, Na Li, Shengli Zhang*, and Lei Zhang*, Membrane Fusion involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation. Frontiers in Molecular Neuroscience, 10:168, 2017.

37. Dongsheng Li*, Jaehun Chun*, Dongdong Xiao, Weijiang Zhou, Huacheng Cai, Lei Zhang, Kevin M. Rosso, Christopher J. Mundy, Gregory K. Schenter, and James J. De Yoreo, Trends in mica-mica adhesion reflect the influence of molecular details on long-range dispersion forces underlying aggregation and coalignment. PNAS, 114(29): 7537-7542 (2017).

38. Zhiwei Yang, Yang Cao, Dongxiao Hao, Xiaohui Yuan, Lei Zhang, and Shengli Zhang*, Binding profiles of cholesterol ester transfer protein with current inhibitors: a look at mechanism and drawback. Journal of Biomolecular Structure and Dynamics, 36: 2567-2580, 2018.

39. Meng Zhang, Dongsheng Lei, Bo Peng, Mickey Yang, Lei Zhang, M. Art Charles, Kerry-Anne Rye, Ronald M. Krauss, Douglas G. Johns, Gang Ren*, Assessing the mechanisms of cholesteryl ester transfer protein inhibitors. BBA - Molecular and Cell Biology of Lipids, 1862 (12): 1606, 2018.

40. Lu Gou, Taoli Jin, Shuyu Chen, Na Li, Dongxiao Hao, Shengli Zhang, and Lei Zhang*, Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein. Chinese Physics B, 27(2):028708, 2018.

41. Shuyu Chen#, Na Li#, Taoli Jin, Lu Gou, Dongxiao Hao, Zhiqi Tian, Shengli Zhang, Lei Zhang*, Lipoprotein in cholesterol transport: Highlights and recent insights into its structural basis and functional mechanism, Chinese Physics B, 27(2):028702, 2018.

42. Zhiwei Yang#, Dongxiao Hao#, Yizhuo Che, Jiahui Yang, Lei Zhang*, and Shenlgi Zhang*, Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors, Chinese Physics B, 27(1):018704, 2018.

43. Dongxiao Hao, Zhiwei Yang, Teng Gao, Zhiqi Tian, Lei Zhang*, and Shengli Zhang*, Role of glycans in cholesteryl ester transfer protein revealed by molecular dynamics simulation, Proteins 86:882-891, 2018.

44. Zhiqi Tian, Michael Crowe, Liqin Shao, Peng Zhang, Lei Zhang*, Qing Zhao*, and Jiajie Diao*, Interface Colloidal Deposition of Nanoparticle Wire Structures, Particle & Particle Systems Characterization, 35:1800098, 2018.

45. QianChun Wang, XiaoBo Zhai, Michael Crowe, Lu Gou, YinFeng Li, DeChang Li*, Lei Zhang*, JiaJie Diao*, and BaoHua Ji*, Heterogeneous Oxidization of Graphene Nanosheets Damages Membrane, Science China Physics, Mechanics & Astronomy, 62(6): 064611, 2019.

46. Hongtao Ren#, Zixin Xiong#, Enze Wang#, Zhiquan Yuan, Yufei Sun, Kunlei Zhu, Bolun Wang, Xuewen Wang, Hanyuan Ding, Peng Liu, Lei Zhang*, Junqiao Wu, Shoushan Fan, Xiaoyan Li*, and Kai Liu*, Watching Dynamic Self-assembly of Web Buckles in Strained MoS2 Thin Films, ACS Nano, 13:3106-3116, 2019

47. Baojun Lin, Lin Zhang, Heng Zhao, Xianbin Xu, Ke Zhou, Song Zhang, Lu Gou, Baobing Fan, Lei Zhang, Hongping Yan, Xiao Dan Gu*, Lei Ying, Fei Huang*, Yong Cao, Wei Ma*, Molecular packing control enables excellent performance and mechanical property of blade-cast all-polymer solar cells, Nano Energy, 59:277-284, 2019

 48. Hongtao Ren, Gang Xiang*, Jiating Lu, Xi Zhang, Lei Zhang*, Biaxial Strain-Mediated Room Temperature Ferromagnetism of ReS2 Web Buckles, Advanced Electronic Materials, 1900814, 2019

49. Boyu Liu#, Fei Liu#, Nan Yang, Xiaobo Zhai, Lei Zhang, Yang Yang, Bin Li, Ju Li, Evan Ma, Jianfeng Nie, Zhiwei Shan*, Large plasticity in magnesium mediated by pyramidal dislocations, Science, 365:73-75, 2019

50. Xiaoman Ma, Fang Pan, Haoqi Li, Peng Shen, Chao Ma, Lei Zhang, Haibo Niu, Youzhang Zhu, Honggang Ye*, Mechanism of Single-Photon Upconversion Photoluminescence in All-Inorganic Perovskite Nanocrystals: The Role of Self-Trapped Excitons, The Journal of Physical Chemistry Letters, 10:5989-5996, 2019

51. Ke Sun#, Changjian Zhao#, Yuejia Chen#, Xiaojun Zeng#, Xin Jiang#, Xianting Ding, Lu Gou, Haiyang Xie, Xinqiong Li, Xialin Zhang, Sheng Lin, Linqin Dou, Long Wei, Haofu Niu, Ming Zhang, Ruocen Tian, Erica Sawyer, Qingyue Yuan, Yuqin Huang, Piaopiao Chen, Chengjian Zhao, Cuisong Zhou, Binwu Ying, Bingyang Shi, Xiawei Wei, Ruotian Jiang, Lei Zhang*, Guangwen Lu*, Jia Geng*, Active DNA Unwinding and Transport by a Membrane-Adapted Helicase Nanopore, Nature Communications, 10:5083, 2019

联系方式
电子邮箱:zhangleio@mail.xjtu.edu.cn
联系电话:029-82668634
个人主页: zhangleio.gr.xjtu.edu.cn
联系地址:陕西省西安市碑林区咸宁西路28号 乐动体育平台官网理学院应用物理系 兴庆校区材料与基础学科大楼B824室
更新日期:2020-09-27